Human Immunodeficiency Virus, Antiretroviral Therapy and Markers of Lymphatic Filariasis Infection: A Cross-sectional Study in Rural Northern Malawi
Identifieur interne : 001D04 ( Main/Exploration ); précédent : 001D03; suivant : 001D05Human Immunodeficiency Virus, Antiretroviral Therapy and Markers of Lymphatic Filariasis Infection: A Cross-sectional Study in Rural Northern Malawi
Auteurs : Terence Tafatatha [Malawi, Royaume-Uni] ; Miriam Taegtmeyer [Royaume-Uni] ; Bagrey Ngwira [Malawi, Royaume-Uni] ; Amos Phiri [Malawi] ; Mariot Kondowe [Malawi] ; Wilson Piston [Malawi] ; Anna Molesworth [Malawi, Royaume-Uni] ; Ndoliwe Kayuni [Malawi] ; Olivier Koole [Malawi, Royaume-Uni] ; Amelia Crampin [Malawi, Royaume-Uni] ; John Horton [Royaume-Uni] ; Neil French [Malawi, Royaume-Uni]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Antigènes d'helminthe (sang), Antirétroviraux (usage thérapeutique), Co-infection (épidémiologie), Facteurs temps, Filariose lymphatique (épidémiologie), Humains, Infections à VIH (traitement médicamenteux), Infections à VIH (épidémiologie), Malawi (épidémiologie), Population rurale (), Prévalence, Études transversales.
- MESH :
- sang : Antigènes d'helminthe.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Antirétroviraux.
- épidémiologie : Co-infection, Filariose lymphatique, Infections à VIH, Malawi.
- Adulte, Facteurs temps, Humains, Population rurale, Prévalence, Études transversales.
- Wicri :
- geographic : Malawi.
English descriptors
- KwdEn :
- Adult, Anti-Retroviral Agents (therapeutic use), Antigens, Helminth (blood), Coinfection (epidemiology), Cross-Sectional Studies, Elephantiasis, Filarial (epidemiology), HIV Infections (drug therapy), HIV Infections (epidemiology), Humans, Malawi (epidemiology), Prevalence, Rural Population (statistics & numerical data), Time Factors.
- MESH :
- chemical , blood : Antigens, Helminth.
- chemical , therapeutic use : Anti-Retroviral Agents.
- geographic , epidemiology : Malawi.
- drug therapy : HIV Infections.
- epidemiology : Coinfection, Elephantiasis, Filarial, HIV Infections.
- statistics & numerical data : Rural Population.
- Adult, Cross-Sectional Studies, Humans, Prevalence, Time Factors.
Abstract
Lymphatic filariasis (LF) and human immunodeficiency virus (HIV) are major public health problems. Individuals may be co-infected, raising the possibility of important interactions between these two pathogens with consequences for LF elimination through annual mass drug administration (MDA).
We analysed circulating filarial antigenaemia (CFA) by HIV infection status among adults in two sites in northern Malawi, a region endemic for both LF and HIV. Stored blood samples and data from two geographically separate studies were used: one a recruitment phase of a clinical trial of anti-filarial agent dosing regimens, and the other a whole population annual HIV sero-survey. In study one, 1,851 consecutive adult volunteers were screened for HIV and LF infection. CFA prevalence was 25.4% (43/169) in HIV-positive and 23.6% (351/1487) in HIV-negative participants (p=0.57). Geometric mean CFA concentrations were 859 and 1660 antigen units per ml of blood (Ag/ml) respectively, geometric mean ratio (GMR) 0.85, 95%CI 0.49-1.50. In 7,863 adults in study two, CFA prevalence was 20.9% (86/411) in HIV-positive and 24.0% (1789/7452) in HIV–negative participants (p=0.15). Geometric mean CFA concentrations were 630 and 839 Ag/ml respectively (GMR 0.75, 95%CI 0.60-0.94). In the HIV-positive group, antiretroviral therapy (ART) use was associated with a lower CFA prevalence, 12.7% (18/142) vs. 25.3% (67/265), (OR 0.43, 95%CI 0.24-0.76). Prevalence of CFA decreased with duration of ART use, 15.2% 0-1 year (n=59), 13.6% >1-2 years (n=44), 10.0% >2-3 years (n=30) and 0% >3-4 years treatment (n=9), p<0.01 χ2 for linear trend.
In this large cross-sectional study of two distinct LF-exposed populations, there is no evidence that HIV infection has an impact on LF epidemiology that will interfere with LF control measures. A significant association of ART use with lower CFA prevalence merits further investigation to understand this apparent beneficial impact of ART.
Url:
DOI: 10.1371/journal.pntd.0003825
PubMed: 26042839
PubMed Central: 4456405
Affiliations:
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sort="Ngwira, Bagrey" uniqKey="Ngwira B" first="Bagrey" last="Ngwira">Bagrey Ngwira</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Karonga Prevention Study, Karonga District, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Karonga Prevention Study, Karonga District</wicri:regionArea><wicri:noRegion>Karonga District</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Phiri, Amos" sort="Phiri, Amos" uniqKey="Phiri A" first="Amos" last="Phiri">Amos Phiri</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Karonga Prevention Study, Karonga District, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Karonga Prevention Study, Karonga District</wicri:regionArea><wicri:noRegion>Karonga District</wicri:noRegion></affiliation></author><author><name sortKey="Kondowe, Mariot" sort="Kondowe, Mariot" uniqKey="Kondowe M" first="Mariot" last="Kondowe">Mariot Kondowe</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Karonga Prevention Study, Karonga District, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Karonga Prevention Study, Karonga District</wicri:regionArea><wicri:noRegion>Karonga District</wicri:noRegion></affiliation></author><author><name sortKey="Piston, Wilson" sort="Piston, Wilson" uniqKey="Piston W" first="Wilson" last="Piston">Wilson Piston</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Karonga Prevention Study, Karonga District, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Karonga Prevention Study, Karonga District</wicri:regionArea><wicri:noRegion>Karonga District</wicri:noRegion></affiliation></author><author><name sortKey="Molesworth, Anna" sort="Molesworth, Anna" uniqKey="Molesworth A" first="Anna" last="Molesworth">Anna Molesworth</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Karonga Prevention Study, Karonga District, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Karonga Prevention Study, Karonga District</wicri:regionArea><wicri:noRegion>Karonga District</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kayuni, Ndoliwe" sort="Kayuni, Ndoliwe" uniqKey="Kayuni N" first="Ndoliwe" last="Kayuni">Ndoliwe Kayuni</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Karonga Prevention Study, Karonga District, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Karonga Prevention Study, Karonga District</wicri:regionArea><wicri:noRegion>Karonga District</wicri:noRegion></affiliation></author><author><name sortKey="Koole, Olivier" sort="Koole, Olivier" uniqKey="Koole O" first="Olivier" last="Koole">Olivier Koole</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Karonga Prevention Study, Karonga District, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Karonga Prevention Study, Karonga District</wicri:regionArea><wicri:noRegion>Karonga District</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Crampin, Amelia" sort="Crampin, Amelia" uniqKey="Crampin A" first="Amelia" last="Crampin">Amelia Crampin</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Karonga Prevention Study, Karonga District, Malawi</addr-line></nlm:aff><country xml:lang="fr">Malawi</country><wicri:regionArea>Karonga Prevention Study, Karonga District</wicri:regionArea><wicri:noRegion>Karonga District</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Horton, John" sort="Horton, John" uniqKey="Horton J" first="John" last="Horton">John Horton</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Tropical Projects, Hitchin, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Tropical Projects, Hitchin</wicri:regionArea><wicri:noRegion>Hitchin</wicri:noRegion></affiliation></author><author><name sortKey="French, Neil" sort="French, Neil" uniqKey="French 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when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anti-Retroviral Agents (therapeutic use)</term><term>Antigens, Helminth (blood)</term><term>Coinfection (epidemiology)</term><term>Cross-Sectional Studies</term><term>Elephantiasis, Filarial (epidemiology)</term><term>HIV Infections (drug therapy)</term><term>HIV Infections (epidemiology)</term><term>Humans</term><term>Malawi (epidemiology)</term><term>Prevalence</term><term>Rural Population (statistics & numerical data)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Antigènes d'helminthe (sang)</term><term>Antirétroviraux (usage thérapeutique)</term><term>Co-infection (épidémiologie)</term><term>Facteurs temps</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (épidémiologie)</term><term>Malawi (épidémiologie)</term><term>Population rurale ()</term><term>Prévalence</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Malawi</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coinfection</term><term>Elephantiasis, Filarial</term><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Rural Population</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirétroviraux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Co-infection</term><term>Filariose lymphatique</term><term>Infections à VIH</term><term>Malawi</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Humans</term><term>Prevalence</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Facteurs temps</term><term>Humains</term><term>Population rurale</term><term>Prévalence</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Malawi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Lymphatic filariasis (LF) and human immunodeficiency virus (HIV) are major public health problems. Individuals may be co-infected, raising the possibility of important interactions between these two pathogens with consequences for LF elimination through annual mass drug administration (MDA).</p></sec><sec id="sec002"><title>Methodology and Principal Findings</title><p>We analysed circulating filarial antigenaemia (CFA) by HIV infection status among adults in two sites in northern Malawi, a region endemic for both LF and HIV. Stored blood samples and data from two geographically separate studies were used: one a recruitment phase of a clinical trial of anti-filarial agent dosing regimens, and the other a whole population annual HIV sero-survey. In study one, 1,851 consecutive adult volunteers were screened for HIV and LF infection. CFA prevalence was 25.4% (43/169) in HIV-positive and 23.6% (351/1487) in HIV-negative participants (p=0.57). Geometric mean CFA concentrations were 859 and 1660 antigen units per ml of blood (Ag/ml) respectively, geometric mean ratio (GMR) 0.85, 95%CI 0.49-1.50. In 7,863 adults in study two, CFA prevalence was 20.9% (86/411) in HIV-positive and 24.0% (1789/7452) in HIV–negative participants (p=0.15). Geometric mean CFA concentrations were 630 and 839 Ag/ml respectively (GMR 0.75, 95%CI 0.60-0.94). In the HIV-positive group, antiretroviral therapy (ART) use was associated with a lower CFA prevalence, 12.7% (18/142) vs. 25.3% (67/265), (OR 0.43, 95%CI 0.24-0.76). Prevalence of CFA decreased with duration of ART use, 15.2% 0-1 year (n=59), 13.6% >1-2 years (n=44), 10.0% >2-3 years (n=30) and 0% >3-4 years treatment (n=9), p<0.01 χ<sup>2</sup> for linear trend.</p></sec><sec id="sec003"><title>Conclusions/Significance</title><p>In this large cross-sectional study of two distinct LF-exposed populations, there is no evidence that HIV infection has an impact on LF epidemiology that will interfere with LF control measures. 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sortKey="Tafatatha, Terence" sort="Tafatatha, Terence" uniqKey="Tafatatha T" first="Terence" last="Tafatatha">Terence Tafatatha</name></noRegion><name sortKey="Crampin, Amelia" sort="Crampin, Amelia" uniqKey="Crampin A" first="Amelia" last="Crampin">Amelia Crampin</name><name sortKey="French, Neil" sort="French, Neil" uniqKey="French N" first="Neil" last="French">Neil French</name><name sortKey="Kayuni, Ndoliwe" sort="Kayuni, Ndoliwe" uniqKey="Kayuni N" first="Ndoliwe" last="Kayuni">Ndoliwe Kayuni</name><name sortKey="Kondowe, Mariot" sort="Kondowe, Mariot" uniqKey="Kondowe M" first="Mariot" last="Kondowe">Mariot Kondowe</name><name sortKey="Koole, Olivier" sort="Koole, Olivier" uniqKey="Koole O" first="Olivier" last="Koole">Olivier Koole</name><name sortKey="Molesworth, Anna" sort="Molesworth, Anna" uniqKey="Molesworth A" first="Anna" last="Molesworth">Anna Molesworth</name><name sortKey="Ngwira, Bagrey" sort="Ngwira, Bagrey" uniqKey="Ngwira B" first="Bagrey" last="Ngwira">Bagrey Ngwira</name><name sortKey="Phiri, Amos" sort="Phiri, Amos" uniqKey="Phiri A" first="Amos" last="Phiri">Amos Phiri</name><name sortKey="Piston, Wilson" sort="Piston, Wilson" uniqKey="Piston W" first="Wilson" last="Piston">Wilson Piston</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Tafatatha, Terence" sort="Tafatatha, Terence" uniqKey="Tafatatha T" first="Terence" last="Tafatatha">Terence Tafatatha</name></noRegion><name sortKey="Crampin, Amelia" sort="Crampin, Amelia" uniqKey="Crampin A" first="Amelia" last="Crampin">Amelia Crampin</name><name sortKey="French, Neil" sort="French, Neil" uniqKey="French N" first="Neil" last="French">Neil French</name><name sortKey="Horton, John" sort="Horton, John" uniqKey="Horton J" first="John" last="Horton">John Horton</name><name sortKey="Koole, Olivier" sort="Koole, Olivier" uniqKey="Koole O" first="Olivier" last="Koole">Olivier Koole</name><name sortKey="Molesworth, Anna" sort="Molesworth, Anna" uniqKey="Molesworth A" first="Anna" last="Molesworth">Anna Molesworth</name><name sortKey="Ngwira, Bagrey" sort="Ngwira, Bagrey" uniqKey="Ngwira B" first="Bagrey" last="Ngwira">Bagrey Ngwira</name><name sortKey="Taegtmeyer, Miriam" sort="Taegtmeyer, Miriam" uniqKey="Taegtmeyer M" first="Miriam" last="Taegtmeyer">Miriam Taegtmeyer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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